Androgens (male hormones) are crucial to female fertility, suggests new CHR publication
Combining the most up-to-date animal data with human data, CHR's fertility experts were able to elucidate the possible synergistic effects of certain androgens (like testosterone and DHEA) and FSH, in the early stages of follicle development. This may lead to a longer-term therapeutic intervention in oocyte maturation for IVF.
For immediate release
August 22, 2011 (New York, NY) Androgens (male hormones), contrary to popular belief, are playing a crucial role in women's fertility. Some androgens and follicle-stimulating hormone (FSH) may work together to encourage development of eggs in the ovary in the early stages of oocyte (egg) maturation, investigators from a New York fertility center suggested in a recent article1.
In a paper just published in the journal Reproductive Biology and Endocrinology, researchers from the Center for Human Reproduction (CHR) reached these conclusions, combining results from human and recent mouse research. Some androgens, such as testosterone and dehydroepiandrosterone (DHEA), may make essential contributions to the normal maturation of follicles that contain eggs in the ovary.
Androgen's role in female fertility has been controversial at best. Some researchers have even insisted that androgens are the principal enemy of follicle maturation, especially given observations in patients with polycystic ovarian syndrome (PCOS), who often present with excess androgens and tend to struggle with infertility.
"Recent research data suggests that androgens and FSH, likely at specific, balanced concentrations, work together in promoting follicle development," explains Norbert Gleicher, MD, lead author of the paper, and Medical Director of CHR. "Investigations of such intricacies of ovarian function cannot be done in humans, at least initially, and requires integration of animal data, which is exactly what we did."
The synergism between androgens and FSH appears most pronounced in the pre-antral and early antral stages of follicle maturation, at least 2-3 months before an egg is ready for ovulation. "This may open new avenues for treatment, especially for women with 'older' ovaries" says David H Barad, MD, another author of the study. "Instead of focusing only on the last two weeks of oocyte maturation, as we currently do with infertility treatments, we may be able to offer treatments that benefit follicle development from much earlier maturation stages."
Dr. Gleicher notes in the publication that doctors at CHR have preliminary evidence that longer-term exposure to DHEA in combination with FSH may positively affect oocyte development, though more definite conclusions require further studies.
11Gleicher N, Weghofer A, Barad DH. The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment? Reprod Biol Endocrinol 2011;9(1):116.
CHR is a leading infertility center in New York City, with world-wide patient clientele, well recognized for its extensive clinical research program, which over the years contributed a number of major breakthrough to the IVF process. Dr. Gleicher is available for additional comments.
Contact:
Communications Manager
212-994-4400 x.4491
###
