Ovulatory Dysfunction

Causes and Treatment Options

Ovulatory Dysfunction Overview

Ovulatory problems account for 20 to 30% of infertility cases. If you suffer from Ovulatory Dysfunction or Ovarian Dysfunction and would like a free e-mail consultation, please complete our Ovulatory Dysfunction FREE Email Consultation Form.

Dr. Norbert Gleicher explains ovarian aging.

A normal adult women ovulates every 25 to 32 days. Ovulation is actually a process of maturing eggs that have been “resting” in the ovaries since birth. Each day throughout a woman’s life until she reaches menopause, a few eggs move from the “resting” state into an “active” state. Even though eggs attempt to become “active” continuously through childhood, they can not mature since there are no hormones to drive their development. Hormones that can allow the “activated” eggs to mature only become available after a women reaches puberty. Once the eggs begin to mature they compete with each other to become “the” egg that will ovulate. After eggs commit to the maturation process, there is no turning backwards, they either achieve successful ovulation or they die.

Ovulatory Dysfunction Causes

CHR Publications on PCOS

  • Lack of association between polycystic ovary syndrome and embryonic aneuploidy.

    Fertility & Sterility NA Weghofer, S Munne, S Chen, DH Barad, N Gleicher. Investigating the rates of aneuploidy (chromosomal abnormalities) in embryos in women with and without PCOS, this study concluded that women with PCOS do not have higher aneuploidy rates. Women with PCOS produce generally more oocytes but demonstrate lower pregnancy rates. The study suggests that the cause for PCOS patients' lower pregnancy rates in association with IVF is likely non-genetic.
  • FMR1 genotype with autoimmunity-associated polycystic ovary-like phenotype and decreased pregnancy chance.

    PLoS ONE N Gleicher, A Weghofer, IH Lee, DH Barad. The study examined the relationship between the FMR1 genotypes and autoimmunity-associated PCO phenotype, characterized by large oocyte yields in IVF. The study found that women with lean PCO phenotype have a significantly higher prevalence of autoimmunity and that het-norm/low FRM1 sub-genotype is strongly associated with autoimmune-related PCO phenotype, as well as significantly reduced IVF pregnancy rates.

More publications

Prematurely Aging Ovaries
The aging ovary is the most common cause of ovulatory problems. In the 10 years before menopause fewer and fewer eggs are present in the ovaries. When the remaining eggs fall below a critical level, cycles can become irregular. Eggs that mature during the last decade of reproductive life, are not as likely to establish a continuing pregnancy. For women who experience irregular cycles secondary to ovarian aging, it may be necessary to use much more fertility medication to achieve ovulation. At CHR we have a special program for Prematurely Aging Ovaries.

Hormonal
Some women have irregular menstruation because their ovaries produce too much androgen (male hormones). These women are often overweight, and have a history of irregular periods, acne, and infertility. This syndrome has been called the Polycystic Ovary Syndrome (PCOS) or PCO, because of the multiple small follicle cysts that can be seen on ultrasound lined up just under the surface of the ovary. In some cases the excess male hormone does not represent PCO. The adrenal gland or the ovary may be sources of abnormal androgen production. Some of these conditions may be dangerous and require further investigation and treatment. Women who do have PCO may benefit by using insulin sensitizing medications, like metformin (Glucophage). Clomiphene citrate (Clomid) is the most common medication used to treat ovulation abnormalities among women with symptoms of PCO. Sometimes these two drugs can be used simultaneously. Your doctor will usually first give you medication such as medroxy-progesterone (Provera) to induce menses. After menstrual flow begins, clomiphene citrate is taken daily from the 3rd through the 7th day of the cycle. Patients may need clomiphene citrate doses of up to 5 pills per day to induce ovulation. It is helpful to monitor the response to this treatment. Acceptable ways of monitoring range from following basal body temperature charts and urinary ovulation predictor kits to daily sonogram monitoring and blood tests.

Stress
Physical or mental stress can result in ovulatory problems. It is not unusual for college or professional school students to stop ovulating. Extreme weight loss, exercise training, even preparation for a piano recital can all result in ovulatory problems. In many cases, these problems are temporary and normal cycling returns when the stressor is no longer present. For women with extreme weight loss an internist, reproductive endocrinologist and psychologist or psychiatrist are often all needed to help correct the problem. Although one could treat this type of anovulatory problem with fertility drugs, most people believe that it is safer and more effective to correct the underlying stressor.

Thyroid
If a woman has either an underactive or over active thyroid (Hypo or Hyperthyroidism) ovulatory problems may occur. Proper treatment of the thyroid abnormality will often restore ovulation.

Prolactin
Prolactin is a pituitary hormone that is normally secreted during and after pregnancy to prepare a woman’s body to produce milk for her baby. Sometimes too much prolactin is secreted from the pituitary when a woman is not pregnant. Not surprisingly, women with this condition often begin to lactate. Discharge of milk and loss of menstruation are the major symptoms associated with this condition. In some cases menses do not stop, but cycles become irregular and there is a shorter interval between menses. Women with this condition need to have a CT scan or MRI to make sure their pituitary is normal. Although in the past these cases sometimes required pituitary surgery, today excess prolactin production can almost always be effectively treated with medication.

Abnormal ovarian development
Some women are born with ovaries that can not produce eggs. Women with this condition do not go through puberty and usually never have a period.

Ovulation Dysfunction Treatment

The good news is that many ovulatory problems can be effectively treated. Once ovulation is restored the chance of pregnancy returns to normal. We are fortunate today that the availability of egg donors can provide an opportunity even for women with ovarian aging or abnormal ovarian development to achieve pregnancy.

The medications used to treat ovulatory problems will depend on their cause. Some medications are known as fertility drugs. These medications are oral medications like clomiphene citrate and injectable medications such as recombinant FSH, highly purified FSH, human menopausal gonadotropins, and human chorionic gonadotrophins. A special class of medications, such as bromocriptine or cabergoline, is used to treat hyperprolactinemia.

Treatment Qualifications

If you have ovulatory dysfunction and unable to get pregnant after trying for one year, please complete the Ovulatory Dysfunction Consultation Form to determine if you qualify for our Treatment Program.

Last Updated: June 28, 2013