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Statement on Chromosomal Testing of Human Embryos Prior to Embryo Transfer

International Group of Prominent Reproductive Physicians and Scientists Releases Position Statement on Chromosomal Testing of Human Embryos Prior to Embryo Transfer

For immediate release

June 1, 2020 (New York, NY) - Preimplantation genetic testing for aneuploidy (PGT-A), previously known as PGS (preimplantation genetic screening), has in recent years become an increasingly frequent add-on to in vitro fertilization (IVF). A recent study by British investigators reported that the procedure in the UK between 2014 and 2016 remained at a 2% utilization rate, while in the U.S. it increased from 13% to 37% [1]. It appears likely that as of 2020, at least half of all IVF cycles in the U.S. utilize PGT-A. Over the last decade, this increasing utilization has, however, also been criticized because reported IVF outcome data did not demonstrate promised outcome improvements in pregnancy and live birth rates. Some data, indeed, suggested that in some patients PGT-A may have the opposite effect and reduce the chances of successful IVF.

Since 2006, a small society, currently only encompassing 272 members worldwide, the Preimplantation Genetic Diagnosis International Society (PGDIS), with headquarters in Oakbrook, IL (tellingly in one of the nation's most prominent PGT-A laboratories), has assumed the role of guiding worldwide PGT-A policies. In doing so, the membership of the PGDIS and its leadership, almost exclusively, represent the genetic testing industry. Following the organization's latest policy guidance in 2019 [2], an international group of prominent physicians and basic scientists spontaneously coalesced under the name of "International Do No Harm Group in IVF" (IDNHG-IVF), with the goal of offering a consensus opinion about the clinical utilization of PGT-A in association with IVF that in many aspects strongly differs from the guidance provided by the PGDIS. This Position Statement from the IDNHG-IVF was just published in the medical journal Reproductive Biology and Endocrinology [3].

This document concludes: "As the PGDIS never suggested any restrictions on the clinical utilization of PGT-A in IVF, here presented rebuttal presents an act of self-regulation by parts of the IVF community in attempts to control increasing utilization of different unproven recent add-ons to IVF."

[1] Theobald et al., The status of preimplantation genetic testing in the UK and USA. Hum Reprod 2020; 35(4):986-998
[2] Cram et al., PGDIS Position Statement on the Transfer of Mosaic Embryos. Reprod Biome Online 2019; 39(suppl 1): e1-4
[3] Gleicher et al., The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A. Reprod Biol Endocrinol 2020;18:57

The paper's first author, Norbert Gleicher, MD, Medical Director and Chief Scientist of New York City's Center for Human Reproduction, is available for further comments.

About Center for Human Reproduction: Center for Human Reproduction (CHR) is a leading fertility treatment and research center in New York City with international reputation for innovative and effective treatments for women with complicated cases of infertility, particularly those with diminished ovarian reserve (DOR).

Norbert Gleicher, MD

Norbert Gleicher, MD, FACOG, FACS

Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned specialist in reproductive endocrinology, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.

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