AMH Levels by Age
How Do Low AMH Levels Affect Fertility?
AMH is one of the most accurate tests to assess a woman's ovarian reserve (OR). Levels of this hormone can be measured at any point of a woman's menstrual cycle. Follicle Stimulating Hormone (FSH) is another important method of ovarian reserve testing. These are used in combination to get a better picture of a patient’s overall ovarian reserve, as each hormone reflects the follicles in the ovaries at different stages of development. Typically, levels move in opposite directions as women age, with AMH going down and FSH going up, indicating the age-related natural deterioration of ovarian reserve.
Low anti-Mullerian hormone and high follicle stimulating hormone levels are indicators of diminished ovarian reserve (DOR), a decline in the ovaries’ ability to produce good-quality eggs. DOR is one of the major causes of infertility among women.
In reverse, high AMH can signal polycystic ovary syndrome (PCOS). While a low level of AMH is usually accompanied by high FSH, when a woman’s AMH levels are normal or high and her FSH levels are also high, this can signal hypoandrogenic PCOS, a relatively new type of PCOS that CHR researchers were the first to identify. CHR’s research has found that patients with hypoandrogenic PCOS, even when they are in their mid- to late 40s, tend to produce a good number of high-quality eggs in IVF cycles, once their low androgen state is corrected with DHEA supplementation. Consequently, these patients also have surprisingly good pregnancy rates with IVF.
What’s the Difference Between AMH and FSH Measurements?
Anti-Mullerian hormone is often measured along with follicle stimulating hormone. However, measurements of these hormones have a few important differences:
- AMH levels can be measured at any time. FSH has to be measured on a specific day in a woman’s cycle, usually on day 3.
- AMH appears to be a better predictor of pregnancy chances than FSH, according to recent research. It has been reported, however, that anti-Mullerian hormone loses its prognostic ability in women above age 42, although it remains a more reliable predictor than follicle stimulating hormone alone. Levels can vary greatly depending on the woman tested and her age.
- AMH levels reflect how many very immature eggs are “on deck” to start the journey toward maturation while FSH levels reflect the eggs that are currently going through the maturation process and will be available for ovulation (or egg retrieval, if going through an IVF cycle).
What is a Normal AMH Level According to Age?
It is important to remember that normal levels change depending on a woman’s age. For example, a normal level for a woman at 42 could suggest premature ovarian aging (POA) if the same level was found in a 32-year-old woman. It’s crucial to evaluate levels of both anti-Mullerian hormone and follicle stimulating hormone in this age-specific way. In this example, the 32-year-old woman would struggle to conceive if she is not diagnosed with POA, or if she is given a one-size-fits-all IVF protocol that does not address her declining ovarian reserve.
So that we can arrive at a timely diagnosis of POA and tailor our treatments for those patients with declining DOR that may not be immediately obvious, CHR researched and established age-specific levels of AMH and FSH. Focusing on these age-specific levels allows us to best assess a woman’s ovarian reserve, devise an appropriate treatment plan and estimate her IVF pregnancy chances.
Anti Mullerian Hormone Levels Chart
|< 33 Years||< 7.0 mIU/mL||= 2.1 ng/mL|
|33-37 Years||< 7.9 mIU/mL||= 1.7 ng/mL|
|38-40 Years||< 8.4 mIU/mL||= 1.1 ng/mL|
|= 41+ Years||< 8.5 mIU/mL||= 0.5 ng/mL|
"Pregnancy is still possible with low AMH."Dr. Norbert Gleicher
Questions About Your AMH Level for IVF?
At CHR, we specialize in advanced fertility treatments and hard-to-treat cases, including women with low, even undetectable, AMH levels. Contact us to learn whether you’re a candidate for treatment.
How to Increase AMH Levels For Better Pregnancy Chances
How can I increase AMH levels to get pregnant? That is a commonly asked question. However, that’s not quite the right way to frame the question, as a low level is just a symptom of a real condition: diminished ovarian reserve. Addressing the causes and negative effects of diminished ovarian reserve is what’s necessary to achieve a successful outcome: a healthy pregnancy and a baby to take home.
Many patients come to CHR after being told by other fertility specialists that their chance of pregnancy is less than 1% because of their low level of AMH and high level of FSH. But proper treatment designed to address problems with the levels of these hormones considerably increases the likelihood of success. In many cases, CHR physicians have found that those “less than 1% chance of pregnancy” prognoses are outright wrong, with many patients having far higher chances of IVF pregnancy using their own eggs, especially if they can produce multiple embryos in an IVF cycle.
A recent analysis of CHR’s IVF outcomes for women with AMH that is very low found that even above age 41, as long as the patient’s ovaries still produce more than two transferable embryos, pregnancy rates were in the 6-7% range. For example, this video explains how one of CHR’s innovative treatment methods doubled pregnancy rates in older women. This means that it’s particularly important to seek out fertility treatments from an IVF center with specialized expertise in treating women with low AMH/DOR.
Read more about Anti-Müllerian Hormone
Anti-Müllerian Hormone (AMH) is a hormone secreted by the cells of the developing...
Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned reproductive endocrinologist, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.
Last Updated: April 24, 2020