Egg Donor Requirements and Egg Donation Process FAQ
Becoming an egg donor is a big decision and commitment. As you think about this opportunity, it is important for you to fully understand our egg donor requirements, the egg donation process, and your responsibilities as an egg donor.
Egg Donor Application and Screening
Before everything else can happen, potential egg donors must apply to our egg donation program and then go through an initial screening process and two rounds of interviews (one with our clinical coordinators and another with our physicians). You will see a doctor for a physical exam, a health history, a family history, and some testing. Only the donor applicants who pass all these screening steps will be added to our egg donor program, and can be matched with a recipient couple. CHR's egg donor program is very selective: on average, we accept only about 1-3% of applicants to our donor program.
Step 1: Egg Donor Matching
When intended parents decide to use donor eggs, they can view the pre-screened pool of egg donors online and select a candidate. A tentative donor egg match is made when a recipient decides to move forward with a specific donor. Our IVF coordinator will contact the egg donor to confirm her availability. If the egg donor is available for the recipient's desired time frame, and passes an FDA-required round of testing, an official match is made. Some donors are selected and matched to a recipient very quickly after they apply; others may take months or years before they are selected; still others may never be selected.
Step 2: Suppression and Ovarian Stimulation for the Egg Donor
The egg donor will self-administer daily injections of a medication called Lupron to suppress her natural cycle, so that her and the recipient's cycles are synchronized. During the ovarian stimulation phase, the egg donor uses daily injections of gonadotropin to stimulate her ovaries. In a natural cycle, only one egg matures; gonadotropins injections encourage more than one egg to mature for retrieval.
During ovarian stimulation, the egg donors are monitored closely through blood tests and ultrasound, ensuring that the ovaries are responding well and not going into hyperstimulation. This means that egg donors need to visit our center in the Upper East Side of Manhattan frequently during this phase. (Long-distance donors go to collaborating IVF centers that are local to them.) These monitoring sessions are scheduled in early morning in order to avoid interfering with the donors' daily schedule of school and work.
Step 3: Endometrial Lining Development for the Donor Egg Recipient
On the recipient's side, a favorable uterine environment, especially an endometrium of at least 7 mm, is crucial in the success of a donor egg cycle. While the egg donor develops eggs for retrieval, the recipient takes estrogen and progesterone to prepare her endometrial lining for implantation. Developing the endometrium for embryo transfer is usually not a problem.
In rare cases, some patients have difficulties in reaching minimal endometrial thickness and may require special treatments. Fortunately, CHR has demonstrated special expertise in this area. Some patients with autoimmune abnormalities may use additional medications to improve the chance of implantation.
Step 4: Triggering Ovulation and Egg Retrieval for the Egg Donor
When the ultrasound imaging shows that the donor's eggs have sufficiently developed, the donor will be instructed to trigger ovulation with an injection of hCG. Two days later, her eggs are retrieved in a short in-office procedure, called egg retrieval. While the donor is asleep (under IV sedation), one of our physicians will use an aspiration needle, guided by ultrasound, to transvaginally retrieve the eggs. The donor will be required to take the rest of the day off to recover.
Long-distance donors who are from another part of the United States will be required to travel to our center in New York City for 3 nights and 2 days for egg retrieval. (Travel costs will be covered.)
Step 5: Fertilization and Embryo Transfer for the Recipient
The retrieved eggs are fertilized with partner's or a donor's sperm. This part of the process is the same as IVF. If using fresh sperm, the partner will need to visit CHR to produce a sample at this time. The embryos that result from this fertilization are incubated and graded. Normally, embryos are transferred into the recipient's uterus on day 3 after donor egg retrieval (on rare occasions on day 5). For our recipients working with our center's egg donor program from outside the NYC metro area, this is the only time they need to be in NYC for the entire cycle. The rest can be managed locally.
Step 6: Post-Retrieval Checkup for the Donor and Pregnancy Tests for the Recipient
The donor will be required to return to our center for a post-retrieval checkup, so that we can make sure that the donor is recovering properly from both the ovarian stimulation and retrieval. In most cases, donors have no problem returning to normal in a day or two after egg retrieval. If this is not the case, our clinical team will closely monitor the donor's progress and stay in touch with her until she fully recovers. From the start of the Lupron injections to egg retrieval, egg donation is a 3-5 week process for most egg donors.
Recipients will have a pregnancy test two weeks after the embryo transfer, via a blood test that measures the level of hCG. After two normally rising hCG tests and an ultrasound demonstrating a pregnancy, recipients are "discharged" to their obstetricians for prenatal care.
Frozen Donor Egg Program (EcoDEP)
CHR also offers a frozen donor egg program called Eco Donor Egg Program (EcoDEP), in which a recipient receives eggs from a donor who has already undergone ovarian stimulation and egg retrieval by the time the recipient chooses her donor. This means that EcoDEP has a different "workflow" from the standard egg donor program described here.
Frequently Asked Questions About Our Standard Egg Donation Program
Egg Donation Logistics
The Egg Donation Process
Side Effects and Risks
After Egg Donation
Egg Donor Selection
Read more about Egg Donation
Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned specialist in reproductive endocrinology, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.