Fertility Research at CHR

Driving Force behind CHR’s Clinical Success

CHR is a rare private fertility center that combines clinical fertility care with a robust clinical and laboratory research program. In over 30 years since its inception, CHR researchers have published hundreds of research papers, many in prestigious medical journals like Journal of the American Medical Association (JAMA) and New England Journal of Medicine (NEJM). CHR’s medical journal publications are listed below.

Some of CHR’s original research findings brought revolutionary new approaches to the field of reproductive endocrinology and infertility. Involvement of autoimmunity in endometriosis is one; the now-routine transvaginal egg retrieval is another; and the most recent example is the introduction of DHEA supplementation into the treatment of women with diminished ovarian reserve.

CHR Explains

CHR’s focus has been the mechanism and treatment of diminished ovarian reserve for over a decade now, and many of our research publications are in this area. In the past few years, CHR has also expanded its laboratory research division significantly with 3 PhD-level scientists to conduct translational research in molecular biology and genetics. CHR’s Medical Director and Chief Scientist, Dr. Norbert Gleicher, emphasizes rigorous translational research because research is what drives innovation in fertility treatment at CHR, and our patients benefit directly from our research findings, which are “translated” into our clinical care program.

Infertility Clinical Trials

Clinical trials are considered the gold standard of research, and at any given time, CHR is likely to have more than one ongoing clinical trials. Some clinical trials recruit participants, while others may be open by invitation only.

CHR’s Medical Journal Publications

Not even noninvasive cell-free DNA can rescue preimplantation genetic testing.

Citation Page #: Epub ahead of print
Journal: Proceedings of the National Academy of Sciences
Author Publication: Gleicher N, Barad DH.
Link: View Publication
Date: 2019

Categories: PGD, PGS & PGT-A, Testing & Diagnostics

Reduced RNA expression of the FMR1 gene in women with low (CGGn<26) repeats.

Citation Page #: 13(12):e0209309.
Journal: PLoS ONE
Author Publication: Wang Q, Barad DH, Darmon SK, Kushnir VA, Wu YG, Lazzaroni-Tealdi E, Zhang L, Albertini DF, Gleicher N.
Link: View Publication
Date: 2018

Categories: Diminished Ovarian Reserve, FMR1, Testing & Diagnostics

Should the reproductive risk of a couple aiming to conceive be tested in the contemporary clinical context?

Citation Page #: 111(2):229-238.
Journal: Fertility & Sterility
Author Publication: Capalbo A, Chokoshvili D, Dugoff L, Franasiak J, Gleicher N, Pennings G, Simon C.
Link: View Publication
Date: 2019

Categories: Testing & Diagnostics

Assessing in-vitro fertilisation at age 40 years.

Citation Page #: 393(10177):1181-1183.
Journal: Lancet
Author Publication: 429. Gleicher N, Barad DH.
Link: View Publication
Date: 2019

Categories: IVF, IVF Success Rates

Patient-centered elective egg freezing: a binational qualitative study of best practices for women’s quality of care.

Citation Page #: 36(6):1081-1090.
Journal: Journal of Assisted Reproduction & Genetics
Author Publication: Inhorn MC, Birenbaum-Carmeli D, Westphal LM, Doyle J, Gleicher N, Meirow D, Dirnfeld M, Seidman D, Kahane A, Patrizio P.
Link: View Publication
Date: 2019

Categories: Egg Freezing & Fertility Preservation

Worldwide live births following the transfer of chromosomally “abnormal” embryos after PGT/A: results of a worldwide web-based survey

Citation Page #: 36(8):1599-1607.
Journal: Journal of Assisted Reproduction & Genetics
Author Publication: 427. Patrizio P, Shoham G, Shoham Z, Leong M, Barad DH, Gleicher N.
Link: View Publication
Date: 2019

Categories: PGD, PGS & PGT-A, Testing & Diagnostics

Unexplained infertility.

Citation Page #: 392(10157):1516-1517.
Journal: Lancet
Author Publication: Gleicher N, Kushnir VA, Barad DH.
Link: View Publication
Date: 2018

Categories: Unexplained Infertility

The pros and cons of preimplantation genetic testing for aneuploidy: clinical and laboratory perspectives.

Citation Page #: 110(3):353-361.
Journal: Fertility & Sterility
Author Publication: 425. Rosenwaks Z, Handyside AH, Fiorentino F, Gleicher N, Paulson RJ, Schattman GL, Scott RT Jr, Summers MC, Treff NR, Xu K.
Link: View Publication
Date: 2018

Categories: IVF Success Rates, PGD, PGS & PGT-A, Testing & Diagnostics

Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women

Citation Page #: 63(3):632-638
Journal: Endocrine
Author Publication: 423. Kushnir VA, Darmon SK, Barad DH, Weghofer A, Gleicher N.
Link: View Publication
Date: 2019

Categories: DHEA

Ten pathways to elective egg freezing: a binational analysis.

Citation Page #: 35(11):2003-2011.
Journal: Journal of Assisted Reproduction & Genetics
Author Publication: Inhorn MC, Birenbaum-Carmeli D, Westphal LM, Doyle J, Gleicher N, Meirow D, Dirnfeld M, Seidman D, Kahane A, Patrizio P.
Link: View Publication
Date: 2018

Categories: Egg Freezing & Fertility Preservation

Elective egg freezing and its underlying socio-demography: a binational analysis with global implications.

Citation Page #: 16(1):70.
Journal: Reproductive Biology & Endocrinology
Author Publication: Inhorn MC, Birenbaum-Carmeli D, Birger J, Westphal LM, Doyle J, Gleicher N, Meirow D, Dirnfeld M, Seidman D, Kahane A, Patrizio P.
Link: View Publication
Date: 2018

Categories: Egg Freezing & Fertility Preservation

Medical egg freezing: How cost and lack of insurance cover impact women and their families

Citation Page #: 5:82-92.
Journal: Reproductive Biomedicine & Science Online
Author Publication: Inhorn MC, Birenbaum-Carmeli D, Westphal LM, Doyle J, Gleicher N, Meirow D, Raanani H, Dirnfeld M, Patrizio P.
Link: View Publication
Date: 2018

Categories: Egg Freezing & Fertility Preservation

Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned reproductive endocrinologist, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.