Older women using their own eggs? Issue framed with two oldest reported IVF pregnancies and a live birth

Published in Reproductive Biomedicine Online.

RESEARCH QUESTION: What level of IVF pregnancy success is currently possible in women of extremely advanced age?

DESIGN: This study reports on outcomes in women aged 43-51 years at the Centre for Human Reproduction, an academically affiliated private clinical fertility and research centre in New York City.

RESULTS: During the study years of 2014-2016, 16 pregnancies were established, all through day 3 transfers. Based on ‘intent to treat’ (cycle start), clinical pregnancy rates were 4/190 (2.1%), 5/234 (2.1%) and 7/304 (2.3%) and live birth rates were 2/190 (1.1%), 1/234 (0.43%) and 4/304 (1.3%) in 2014, 2015 and 2016, respectively. With reference to embryo transfer, clinical pregnancy rates were 4/140 (2.9%), 5/159 (3.1%) and 7/167 (4.2%) and live birth rates were 2/140 (1.4%), 1/159 (0.63%) and 4/167 (2.4%) for the same years. The results for 2016 also included what are probably the two oldest autologous IVF pregnancies ever reported in the literature. These results were obtained with patient ages, percentage of cycle cancellations and other adverse outcome parameters steadily increasing year by year.

CONCLUSIONS: Female age above 42 is widely viewed as the ultimate barrier to conception with IVF. Data reported here, although small and preliminary, demonstrate that potential outcomes are better than widely perceived, while pregnancy and live birth rates remain significantly inferior to donor egg recipient cycles. However, for selected women at very advanced ages, especially with higher egg/embryo numbers, autologous oocyte IVF offers a better option than widely acknowledged, if they are given individualized age-specific care.

Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned reproductive endocrinologist, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.

Citation Page #: 37(2):172-177.
Journal: Reproductive Biomedicine Online
Author Publication: Gleicher N, Kushnir VA, Darmon SK, Albertini DF, Barad DH.
Publication Link: https://linkinghub.elsevier.com/retrieve/pii/S1472-6483(18)30292-X
Date: 2018