Fertility Research at CHR

Driving Force behind CHR’s Clinical Success

CHR is a rare private fertility center that combines clinical fertility care with a robust clinical and laboratory research program. In over 30 years since its inception, CHR researchers have published hundreds of research papers, many in prestigious medical journals like Journal of the American Medical Association (JAMA) and New England Journal of Medicine (NEJM). CHR’s medical journal publications are listed below.

Some of CHR’s original research findings brought revolutionary new approaches to the field of reproductive endocrinology and infertility. Involvement of autoimmunity in endometriosis is one; the now-routine transvaginal egg retrieval is another; and the most recent example is the introduction of DHEA supplementation into the treatment of women with diminished ovarian reserve.

CHR Explains

CHR’s focus has been the mechanism and treatment of diminished ovarian reserve for over a decade now, and many of our research publications are in this area. In the past few years, CHR has also expanded its laboratory research division significantly with 3 PhD-level scientists to conduct translational research in molecular biology and genetics. CHR’s Medical Director and Chief Scientist, Dr. Norbert Gleicher, emphasizes rigorous translational research because research is what drives innovation in fertility treatment at CHR, and our patients benefit directly from our research findings, which are “translated” into our clinical care program.

Infertility Clinical Trials

Clinical trials are considered the gold standard of research, and at any given time, CHR is likely to have more than one ongoing clinical trials. Some clinical trials recruit participants, while others may be open by invitation only.

CHR’s Medical Journal Publications

Pessimism and Optimism

Citation Page #: 81:221
Journal: Fertility and Sterility
Author Publication: Gleicher N
Link: View Publication
Date: January, 2004

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Bye-bye urinary gonadotrophins?

Citation Page #: 18:476-482
Journal: Human Reproduction
Author Publication: Gleicher N, Vietzke M, Vidali A
Link: View Publication
Date: 2003

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Modern obstetrical and infertility care may increase the prevalence of disease: an evolutionary concept

Citation Page #: 79:248-252
Journal: Fertility and Sterility
Author Publication: Gleicher N
Link: View Publication
Date: February, 2003

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Differences in ovarian function parameters between Chinese and Caucasian oocyte donors: do they offer an explanation for lower IVF pregnancy rates in Chinese women?

Chinese egg donors were 30x more likely to have high FSH than Caucasians: a possible explanation for lower IVF pregnancy rates in Chinese women.

Citation Page #: doi:10.1093/HumReprod/dem289
Journal: Hum Reprod
Author Publication: Gleicher N, Weghofer A, JiangMi Li, Barad D
Link: View Publication
Date: 2007

Categories: Diminished Ovarian Reserve, Egg Donation, High FSH, Testing & Diagnostics

Functional autoantibodies, a new paradigm in autoimmunity?

Citation Page #: doi/10.1016/j.autrev.2007.06.001
Journal: Autoimmunity Reviews
Author Publication: Gleicher et al.
Link: View Publication
Date: 2007

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Gender selection for nonmedical indications

Discussion of gender selection for non-medical, family-balancing reasons.

Citation Page #: 78:460-462
Journal: Fertility and Sterility
Author Publication: Gleicher N, Karande V
Link: View Publication
Date: September, 2002

Categories: Gender Selection

The Immunological ‘War of Roses’; Disagreements amongst Reproductive Immunologists

Citation Page #: 17:539-542
Journal: Human Reproduction
Author Publication: Gleicher N, Vidali A, Karande V
Link: View Publication
Date: 2002

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Cost effective infertility care

Citation Page #: 6(2):190-199
Journal: Human Reproduction
Author Publication: Gleicher N
Link: View Publication
Date: 2000

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The Consumer and Provider:

Citation Page #: 26(2):38-43
Journal: The Physician Executive
Author Publication: Gleicher N
Date: March-April 2000

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Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins.

Citation Page #: 1:2-7
Journal: New England Journal of Medicine
Author Publication: Gleicher N, Oleske D, Tur-Kaspa I, Vidali A, Karande V
Link: View Publication
Date: 2000

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Generic Human Menopausal Gonadotropin (hMG) in Place Of More Costly Follicle-Stimulating Hormone (FSH) for Routine Ovulation Induction.

Citation Page #: 17:489-495
Journal: Journal of Assisted Reproduction Genetics
Author Publication: Gleicher N, Karande V
Link: View Publication
Date: 2000

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Prospective randomized trial comparing the outcome and cost of in vitro fertilization with that of a traditional treatment algorithm as first-line therapy for couples with infertility.

Citation Page #: 71(3):468-475
Journal: Fertility & Sterility
Author Publication: Karande V, Korn A, Morris R, Rao R, Balin M, Rinehart J, Dohn K, Gleicher N
Link: View Publication
Date: March 1999

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Octreotide is not useful for chlomiphene citrate resistance in patients with polycystic ovary syndrome but may reduce the likelihood of ovarian hyperstimulation syndrome.

Citation Page #: 71(3):452-456
Journal: Fertility & Sterility
Author Publication: Morris S, Karande V, Dudkiewicz A, Morris J, Gleicher N
Link: View Publication
Date: March 1999

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Impact of the "physician factor" on pregnancy rates in a large assisted reproductive technology program:

Citation Page #: 71(6):1001-1009
Journal: Fertility & Sterility
Author Publication: Karande V, Morris R, Chapman C, Rinehart J, Gleicher N
Date: June 1999

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Reproductive failure prior to the onset of clinical autoimmune disease.

Citation Page #: 38:485-487
Journal: Rheumatology
Author Publication: Gleicher N
Date: 1999

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OPINION – A Rational Approach to the Management of Low Responders in In-Vitro Fertilization.

Citation Page #: 14(7):1744-1748
Journal: Human Reproduction
Author Publication: Karande V, Gleicher N
Link: View Publication
Date: 1999

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Report of the committee for establishing criteria for diagnosis of reproductive autoimmune system.

Citation Page #: 41:121-132
Journal: American Journal Reproduction Immunology
Author Publication: Coulam C, Branch D, Clark D, Gleicher N, Kutteh W, Lockshin M, Rote N
Link: View Publication
Date: 1999

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The Contribution of Estrogen and growth factors to increased Adrenal Androgen secretion in policystic ovary syndrome.

Citation Page #: 14 (2)307-11
Journal: Human Reproduction
Author Publication: Carmia E, Gonzalez F, Vidali A, Stanczyk F, Ferin M, Lobo R
Link: View Publication
Date: 1999

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The Value of Intraoperative Cystoscopy at the time of Laparoscopic Hysterectomy.

Citation Page #: Vol. 14, No. 7
Journal: Human Reproduction
Author Publication: Ribeiro S, Reich C, Rosenberg H, Guglielminetti E, Vidali A
Link: View Publication
Date: 1999

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Laparoscopic Myomectomy In Infertile Patients.

Citation Page #: 71 (3):571-574
Journal: Fertility & Sterility
Author Publication: Ribeiro S, Reich H, Rosenberg J, Guglielminetti E , Vidali A
Date: 1999

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