Fertility Research at CHR

Driving Force behind CHR’s Clinical Success

CHR is a rare private fertility center that combines clinical fertility care with a robust clinical and laboratory research program. In over 30 years since its inception, CHR researchers have published hundreds of research papers, many in prestigious medical journals like Journal of the American Medical Association (JAMA) and New England Journal of Medicine (NEJM). CHR’s medical journal publications are listed below.

Some of CHR’s original research findings brought revolutionary new approaches to the field of reproductive endocrinology and infertility. Involvement of autoimmunity in endometriosis is one; the now-routine transvaginal egg retrieval is another; and the most recent example is the introduction of DHEA supplementation into the treatment of women with diminished ovarian reserve.

CHR Explains

CHR’s focus has been the mechanism and treatment of diminished ovarian reserve for over a decade now, and many of our research publications are in this area. In the past few years, CHR has also expanded its laboratory research division significantly with 3 PhD-level scientists to conduct translational research in molecular biology and genetics. CHR’s Medical Director and Chief Scientist, Dr. Norbert Gleicher, emphasizes rigorous translational research because research is what drives innovation in fertility treatment at CHR, and our patients benefit directly from our research findings, which are “translated” into our clinical care program.

Infertility Clinical Trials

Clinical trials are considered the gold standard of research, and at any given time, CHR is likely to have more than one ongoing clinical trials. Some clinical trials recruit participants, while others may be open by invitation only.

CHR’s Medical Journal Publications

Autoantibodies in infertility: current opinion.

Citation Page #: 2:169-176
Journal: Human Reproduction
Author Publication: Gleicher N
Link: View Publication
Date: 1998

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Cost considerations with infertility treatment therapy: outcome and cost comparison between HMO and PPO care based on physician and facility cost.

Citation Page #: 5:1200-1205
Journal: Human Reproduction
Author Publication: VanderLaan B, Karande V, Krohm C, Morris R, Pratt D, Gleicher N
Link: View Publication
Date: 1998

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Strategies to improve insurance coverage for infertility services.

Citation Page #: 70:1006-1008
Journal: Fertility & Sterility
Author Publication: Gleicher N
Date: 1998

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Follicular fluid Insulin like growth factor – 1 and insulin like growth factor binding protein – 1 and – 3 vary as a function of ovarian reserve and ovarian stimulation.

Citation Page #: 15 (10):587-93
Journal: Journal of Assisted Reproduction Genetics
Author Publication: Stadtmauer L, Vidali A, Lindheim S, Sauer M
Link: View Publication
Date: 1998

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Antiphospholipid antibodies and reproductive failure:

Citation Page #: 12:13-15
Journal: Human Reproduction
Author Publication: Gleicher N
Link: View Publication
Date: 1997

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What is radiation exposure to patients during a gynecoradiologic procedure?

Citation Page #: 2:401-403
Journal: Fertility & Sterility
Author Publication: Gleicher N, Karande V, Balin M, Levrant S, Morris R, Pratt D
Link: View Publication
Date: 1997

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Lysis of intrauterine adhesions using gynecoradiologic techniques.

Citation Page #: 4:658-662
Journal: Fertility & Sterility
Author Publication: Karande V, Levrant S, Hoxsey R., Rinehart J, Gleicher N
Date: 1997

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Estradiol/progesterone substitution in the luteal phase improves pregnancy rates in simulated cycles – but only in younger women.

Citation Page #: ...
Journal: in press by Parthenon's offices, U.K.
Author Publication: Gleicher N, Brown T, Dudkiewicz A, Karande V, Rao R, Balin M, Campbell D, Pratt D
Date: ...

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Limited success using the "flare" protocol in poor responders in cycles with low basal follicle-stimulating hormone levels during in vitro fertilization.

Citation Page #: 67:900-903
Journal: Fertility & Sterility
Author Publication: Karande V, Morris R, Rinehart J, Miller C, Rao R, Gleicher N
Date: 1997

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DEBATE – Ovarian Infertility -Are we overlooking (auto) immune ovarian infertility?

Citation Page #: 12:637-639
Journal: Human Reproduction
Author Publication: Gleicher N, Coulam C
Link: View Publication
Date: 1997

Categories: Pregnacy After 40

Poor Responders to Ovarian Hyperstimulation may benefit from an attempt at natural cycle oocyte retrieval.

Citation Page #: 14 (3):152-156
Journal: Journal Assisted Reproduction Genetics
Author Publication: Lindheim S, Ditkoff E, Vidali A, Sauer M
Date: 1997

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The Utility of Serum Progesterone and Inhibin A for Monitoring Natural Cycle IVF-ET.

Citation Page #: 15 (9):538-541
Journal: Journal Assisted Reproduction Genetics
Author Publication: Lindheim S, Chang P, Vidali A, Ferin M, Sauer M
Date: 1997

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Background pregnancy rates in an infertile population.

Citation Page #: 11:1011-1012
Journal: Human Reproduction
Author Publication: Gleicher N, VanderLaan B, Pratt D, Karande V
Link: View Publication
Date: 1996

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The diagnosis of proximal tubal disease.

Citation Page #: 11:1825-1828
Journal: Human Reproduction
Author Publication: Gleicher N, Karande V
Link: View Publication
Date: 1996

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Patient drop-out rates during infertility therapy are considerable and vary with coverage.

Citation Page #: 88:289-293
Journal: Obstetics Gynecology
Author Publication: Gleicher N, VanderLaan B, Karande V, Morris R, Nadherney K, Pratt D
Date: 1996

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The Assessment of Tubal Functional Status by Tubal Perfussion Pressure Measurements.

Citation Page #: 2:429-433
Journal: Human Reproduction
Author Publication: Karande V, Pratt D, Gleicher N
Link: View Publication
Date: 1996

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