Fertility Research at CHR

Driving Force behind CHR’s Clinical Success

CHR is a rare private fertility center that combines clinical fertility care with a robust clinical and laboratory research program. In over 30 years since its inception, CHR researchers have published hundreds of research papers, many in prestigious medical journals like Journal of the American Medical Association (JAMA) and New England Journal of Medicine (NEJM). CHR’s medical journal publications are listed below.

Some of CHR’s original research findings brought revolutionary new approaches to the field of reproductive endocrinology and infertility. Involvement of autoimmunity in endometriosis is one; the now-routine transvaginal egg retrieval is another; and the most recent example is the introduction of DHEA supplementation into the treatment of women with diminished ovarian reserve.

CHR Explains

CHR’s focus has been the mechanism and treatment of diminished ovarian reserve for over a decade now, and many of our research publications are in this area. In the past few years, CHR has also expanded its laboratory research division significantly with 3 PhD-level scientists to conduct translational research in molecular biology and genetics. CHR’s Medical Director and Chief Scientist, Dr. Norbert Gleicher, emphasizes rigorous translational research because research is what drives innovation in fertility treatment at CHR, and our patients benefit directly from our research findings, which are “translated” into our clinical care program.

Infertility Clinical Trials

Clinical trials are considered the gold standard of research, and at any given time, CHR is likely to have more than one ongoing clinical trials. Some clinical trials recruit participants, while others may be open by invitation only.

CHR’s Medical Journal Publications

A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice

Through a review of medical literature and ongoing clinical trials, this study revealed that there is no evidence that preimplantation genetic screening (PGS) improves IVF success rates, despite the recent introduction of new technical abilities. This article is an important warning against “routine” clinical use of PGS for that indication.

Citation Page #: 29(11):1159-66.
Journal: J Assist Reprod Genet
Author Publication: Gleicher N and Barad DH.
Link: View Publication
Date: 2012

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The irrational attraction of elective single embryo transfer (eSET)

Citation Page #: 28(2):294-7
Journal: Hum Reprod
Author Publication: Gleicher N and Barad DH.
Link: View Publication
Date: 2013 [Epub 2012]

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Differences in ovarian aging patterns between races are associated with ovarian genotypes and sub-genotypes of the FMR1 gene

Citation Page #: 10:77
Journal: Reprod Biol Endocrinol
Author Publication: Gleicher N, Kim A, Weghofer A, Barad DH.
Link: View Publication
Date: 2012

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The impact of androgen metabolism and FMR1genotypes on pregnancy potential in women with dehydroepiandrosterone (DHEA) supplementation

Citation Page #: 27(11):3287-93.
Journal: Human Reproduction
Author Publication: Weghofer A, Kim A, Barad DH, Gleicher N.
Link: View Publication
Date: 2012

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BRCA1/2 mutations appear embryo-lethal unless rescued by low (CGG 26) FMR1 sub-genotypes: an explanation for the BRCA paradox?

: In a groundbreaking study expanding outside the field of fertility, CHR investigators identified a specific genotype (low) of the FMR1 gene associated with unusually high prevalence of BRCA1/2 mutations. If confirmed, the result may open doors to a new, much less costly, tool for breast cancer screening. Read more.

Citation Page #: 7(9):e44753.
Journal: PLoS ONE
Author Publication: Weghofer A, Tea M-K, Barad DH, Kim A, Singer CF, Wagner K, Gleicher N.
Link: View Publication
Date: 2012

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Lessons from elective in vitro fertilization (IVF) in, principally, non-infertile women

PGS may improve pregnancy rates in non-infertile patients undergoing elective IVF cycles, if not in older women.

Citation Page #: 10:48.
Journal: Reprod Biol Endocrinol
Author Publication: Gleicher N, Kim A, Weghofer A, Barad DH.
Link: View Publication
Date: 2012

Categories: Gender Selection, PGD, Pregnacy After 40

Intermediate and normal sized CGG repeat on the FMR1 gene does not negatively affect donor ovarian response (Letter to the Editor)

A comment to the 2012 Hum Reprod article “Intermediate and normal sized CGG repeat on the FMR1 gene does not negatively affect…”

Citation Page #: 27(7):2241-2.
Journal: Human Reproduction
Author Publication: Gleicher N, Weghofer A, Barad DH.
Link: View Publication
Date: 2012

Categories: Egg Donation, FMR1, Testing & Diagnostics

Follicle Stimulating Hormone and Anti-Müllerian Hormone per Oocyte in Predicting in vitro Fertilization Pregnancy in High Responders: A Cohort Study

FSH per retrieved oocyte was IVF predictive of pregnancy chances in high responders, even though FSH and AMH themselves were not.

Citation Page #: 7(4): e34290.
Journal: PLoS ONE
Author Publication: Weghofer A, Kim A, Barad DH, Gleicher N.
Link: View Publication
Date: 2012

Categories: Anti-Müllerian Hormone, High FSH, IVF, Testing & Diagnostics

Hype or hope? Ethical and practical considerations in association with clinical research in women with diminished ovarian reserve

Citation Page #: 25(2):98-102.
Journal: RBMOnline
Author Publication: Gleicher N and Barad DH.
Link: View Publication
Date: 2012

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Comparison of ovarian FMR1 genotypes and sub-genotypes in oocyte donors and infertile women

Egg donors had a similar distribution of FMR1 genotypes as infertility patients, with a subtle difference in het sub-genotypes.

Citation Page #: 29(6): 529-532..
Journal: Journal of Assisted Reproduction and Genetics
Author Publication: Gleicher N, Weghofer A, Kim A, Barad DH.
Link: View Publication
Date: 2012

Categories: Egg Donation, FMR1, Testing & Diagnostics

The impact in older women of ovarian FMR1 genotypes and sub-genotypes on ovarian reserve

Citation Page #: e33638.
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Journal: PLoS One
Author Publication: Gleicher N, Weghofer A, Kim A, Barad DH.
Link: View Publication
Date: 2012

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Follicle stimulating hormone and anti-Müllerian hormone per oocyte in predicting in vitro fertilization pregnancy in high responders: a cohort study

Citation Page #: 7(4): e34290.
Journal: PLoS One
Author Publication: Weghofer A, Barad DH, Kim A, Gleicher N.
Link: View Publication
Date: 2012

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Towards a better understanding of functional ovarian reserve: AMH (AMHo) and FHS (FHSo) hormone ratios per retrieved oocyte.

FSH per retrieved oocytes was found to be predictive of IVF pregnancy chances in women with normal FMR1 genotypes.

Citation Page #: 97(3):995-1004.
Journal: J Clin Endocrinol Metab
Author Publication: Gleicher N, Kim A, Weghofer A, Barad DH.
Link: View Publication
Date: 2012 (Epub 2011)

Categories: Anti-Müllerian Hormone, Diminished Ovarian Reserve, High FSH, IVF, Testing & Diagnostics

A case-control pilot study of low intensity in vitro fertilization (LI-IVF) in good prognosis patients

Citation Page #: 24(4):396-402.
<strong class="summary">Summary
Journal: Reproductive BioMedicine Online
Author Publication: Gleicher N, Weghofer A, Barad DH.
Link: View Publication
Date: 2012 (Epub in 2011)

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Patterns and predictors of sexual activity among women in the Hormone Therapy trials of the Women’s Health Initiative

Citation Page #: 18(11):1160-71.
Journal: Menopause
Author Publication: Gass MH, et al.
Link: View Publication
Date: 2011

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Eliminating multiple pregnancies: an appropriate target for government intervention?

Citation Page #: 23(4):403-6.
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Journal: Reprod Biomed Online
Author Publication: Gleicher N.
Link: View Publication
Date: 2011

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Low-intensity IVF: real progress?

Citation Page #: 23(3)247-8.
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Journal: Reprod Biomed Online
Author Publication: Gleicher N, Weghofer A, Barad DH.
Link: View Publication
Date: 2011

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The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment?

This review theorized that androgens like DHEA may improve the early follicle development at certain therapeutic concentrations.

Citation Page #: 9(1):116
Journal: Reproductive Biology & Endocrinology
Author Publication: Gleicher N, Weghofer A, Barad DH.
Link: View Publication
Date: 2011

Categories: DHEA, Diminished Ovarian Reserve

Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery.

Citation Page #: 9(1):98
Journal: Reproductive Biology & Endocrinology
Author Publication: Weghofer A, Dietrich W, Ortner I, Bieglmayer C, Barad D, Gleicher N.
Link: View Publication
Date: 2011

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To the Editor, on Sunkara et al.

Citation Page #: E-letter [<a href="http://humrep.oxfordjournals.org/content/early/2011/04/18/humrep.der106/reply#humrep_el_182">online only</a>]
Journal: Human Reproduction
Author Publication: Gleicher N, Weghofer A, Barad DH.
Link: View Publication
Date: 2011

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