Anti-Mullerian Hormone (AMH)
AMH and FSH
AMH is one of the most accurate tests to assess a woman's ovarian reserve (OR)ovarian reserve (OR) . AMH levels can be measured at any point of a woman's menstrual cycle. Low AMH is an indicator of diminished ovarian reserve (DOR), a decline in the ovaries’ ability to produce good-quality eggs. DOR is one of the major causes of infertility among women. In reverse, high AMH can signal polycystic ovary syndrome (PCOS).
AMH levels are often measured along with follicle stimulating hormone (FSH) levels, another common measure of a woman's ovarian reserve. AMH has a few advantages over FSH: For one, AMH levels can be measured at any time, while FSH has to be measured on a specific day in her cycle; for another, according to recent research, AMH appears to be a better predictor of pregnancy chances than FSH. It has been reported, however, that AMH loses its prognostic ability in women above age 42, although it remains a more reliable predictor than FSH alone.
Age and AMH
It is important to remember that AMH levels decline and FSH levels increase as women age. In other words, normal AMH and FSH levels vary depending on a woman’s age. For example, a normal AMH level for a woman at 42 could suggest premature ovarian aging (POA) if the same AMH level was found in a 32-year-old woman. Because of this, CHR researched and established age-specific levels of AMH and FSH. Focusing on age-specific AMH and FSH levels allows us to best assess a woman’s ovarian reserve, devise an appropriate treatment plan and estimate her IVF pregnancy chances.
Age Specific Baseline FSH and AMH Levels
|< 33 Years||< 7.0 mIU/mL||= 2.1 ng/mL|
|33-37 Years||< 7.9 mIU/mL||= 1.7 ng/mL|
|38-40 Years||< 8.4 mIU/mL||= 1.1 ng/mL|
|= 41+ Years||< 8.5 mIU/mL||= 0.5 ng/mL|
Pregnancy Chances and AMH Levels
Many patients come to CHR after being told by other fertility specialists that their chance of pregnancy is less than 1% because of their low AMH levels. This dismal prognosis may not hold true with proper treatment designed to address low AMH/DOR. A recent analysis of CHR’s IVF outcomes for women with very low AMH found that even above age 41, as long as the patient’s ovaries still produce more than two transferrable embryos, pregnancy rates were in the 6-7% range. This means that it’s particularly important to seek out fertility treatments from an IVF center with a specialized expertise in treating women with low AMH/DOR.
Last Updated: April 10, 2017