Diminished Ovarian Reserve
What is DOR?
The ability of a woman's ovaries to produce high-quality eggs (and ultimately good-quality embryos) is known as ovarian reserve (OR). One of the major conditions leading to infertility in women, diminished ovarian reserve (DOR) is characterized by a low number of eggs in a woman's ovaries and/or impaired development of the existing eggs. CHR has special expertise in treating women with DOR, born out of our decade-long research on the condition.
Women with untreated DOR have a hard time conceiving. Moreover, when they do conceive, they experience the highest miscarriage rates of any infertility diagnosis. This is because approximately 95 percent of embryo quality comes from the eggs, and poor-quality embryos are less likely to develop and implant in the uterus, and more likely to result in miscarriages.
"CHR has led decades of research and pioneered the use of DHEA, now a key treatment for DOR."Dr. Norbert Gleicher
Diminished ovarian reserve occurs as women get older. With age, ovarian reserve naturally declines. Women attempting pregnancy after age 40 often have difficulty getting pregnant for this reason. However, DOR is not a condition exclusive to women over 40. It can affect younger women as well.
Approximately 10 percent of women begin this usually age-related decline of ovarian function much earlier in life, meaning that if their ovarian reserve is evaluated, it is found to be lower than what is expected for their age. These women are considered to suffer from premature ovarian aging (POA)(POA) , a clinical term coined by CHR researchers. Like women with DOR, women with POA have a hard time conceiving on their own and even with fertility treatments, as they are often misdiagnosed and given inappropriate treatments for their ovarian reserve status. However, with appropriate diagnosis and treatment, many of CHR's POA patients have been able to successfully conceive.
Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned reproductive endocrinologist, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.
Last Updated: October 8, 2018