GrandRounds in New York City

CME Event Series for OBGYN, REI Physicians & Scientists

CHR's GrandRounds are co-sponsored by the Foundation for Reproductive Medicine (FRM). Starting in September 2017, cost of registration per person is $100, payable to the FRM. All GrandRounds events are free of charge for members of the FRM. Memberships in the FRM can be obtained through a minimum annual donation of $1,000 to the FRM, which is tax-deductible according to the law. For payment of the registration fee and FRM membership, please visit the FRM website where donations can be made via PayPal.

PGS or Preimplantation Genetic Testing for Aneuploidy, as it is now suddenly renamed: The most controversial add-on in the history of IVF

Tuesday, September 5th

For the GrandRounds on September 5th, Norbert Gleicher, MD, Medical Director and Chief Scientist of the CHR, will discuss the danger of commercially driven push for PGS.

Norbert Gleicher, MD

Medical Director and Chief Scientist, The CHR, President, FRM, Guest Investigator, The Rockefeller University, Professor (Adj.), Department of Obstetrics and Gynecology, Medical University of Vienna, Austria
Dr. Gleicher has published hundreds of peer-reviewed scientific papers, abstracts and book chapters in reproductive endocrinology and infertility, relating to medical complications in pregnancy and to the immune system in reproduction. He served as founding Editor-in-Chief for the American Journal of Reproductive Immunology (AJRI), and for 30 years of the Journal of In Vitro Fertilization and Embryo Transfer, in 1992 renamed Journal of Assisted Reproduction and Genetics (JARG), now the 2nd official organ of the American Society for Reproductive Medicine (ASRM). He in addition served as editor and/or editorial board member on many other medical journals, and edited a number of major textbooks. Currently, he serves as Academic Editor for PLoS ONE, and is a member of multiple editorial boards. In 2009, Dr. Gleicher was invited to give the prestigious bi-annual Patrick Steptoe Memorial Lecture to the British Fertility Society, as recognition of his contributions to advancements in reproductive endocrinology and infertility. In demand as a speaker, Dr. Gleicher travels extensively worldwide, while maintaining his role in clinical patient care and research at CHR, and as one of the most prolific scientific writers in the specialty.


Context

It now appears time to say good-bye to a term we have been using since the late 1990s, when European colleagues first coined it: Preimplantation genetic screening (PGS), then considered a small sub-category of preimplantation genetic diagnosis (PGD) that described chromosomal testing of human embryos prior to transfers. At least, American Society for Reproductive Medicine (ASRM) and Fertility & Sterility (F&S), the official journal of the ASRM, no longer considers PGS the appropriate term to describe a chromosomal analysis of human embryos. Instead, the May issue of F&S, largely dedicated to the procedure, suddenly, and without further explanation, was referring to the procedure as preimplantation genetic testing for aneuploidy (PGT-A). And for those who considered that a coincidence, the recent preliminary draft of a Practice Committee Opinion of ASRM and Society for Assisted Reproduction (SART) had as its short tile, PGT-A for “aneuploidy.” This lecture will dissect the commercial motivation behind this name change in an attempt to rescue the costly yet clinically unproven test from increasing doubts in the international REI community.


Objectives

At the end of the lecture, learners should be able to:

  • Explain the contradictions between the PGS hypothesis and embryo biology
  • Describe how radically PGS reporting has changed since July 2016
  • List the shortcomings of the new PGDIS guidelines for PGS
  • Describe the clinical utility of PGS in IVF

Agenda

Cocktails: 6 PM at the Center for Human Reproduction (21 E 69th Street, New York, NY 10021)

Lecture: 7 PM at Le Charlot Restaurant (next door to CHR)

Complimentary Dinner: 8 PM at Le Charlot Restaurant (next door to CHR)


Venue

Le Charlot Restaurant

19 E 69th Street
New York, NY 10021
212-794-6419

An intimate French bistro on the Upper East side with a Parisian flair, Le Charlot has been serving French classics like mussels, steak tartar, steak au poivre and decadant chocolate moose for a good number of years. Choosing a good wine to accompany the meal will not be a problem, as their wine list is 20+ pages long. Please join us for scientific exploration followed by fun and festivities.


The Center for Human Reproduction (CHR) has, following its charter, for over 20 years been an independent provider of complimentary continuous medical education. CHR takes full responsibility for balance, objectivity and scientific rigor of all information presented. Selection of speakers, topics and content is independent of all outside commercial interests. These events accept reservation on a first-come, first-served basis. CHR reserves the right to refuse entry to the event once capacity is reached.


To reserve your seat, please fill out the reservation form below.

  • Participation in GrandRounds is free of charge for individuals who become “Members” of the FRM for an annual donation to the FRM of at least $1,000. Donations to the Foundation are tax-deductible according to the law. Membership in the FRM and attendance is also open to CHR patients and potential commercial sponsors.
  • For non-Members, there is a $100 charge for participation in GrandRounds events, charged at reservation time.
  • Registration fee is non-refundable, unless reservations are cancelled at least 48 hours prior to the event.
  • Your registration is not complete until payment is received or your membership status is confirmed. Payment can be made on the FRM website through PayPal.
  • You will receive an email confirmation of your registration upon payment or membership verification.

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Additional Resources

A short summary of CHR’S involvement in PGS history 1998 Verlinsky et al propose PGS via polar body biopsy [Preimplantation diagnosis of common aneuploidies by the first and second

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The 3 most frequently missed diagnoses in infertility work-ups When couples fail to conceive within an expected time frame (which, of course, changes with advancing age), we assign them

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