GrandRounds in New York City

CME Event Series for OBGYN, REI Physicians & Scientists

Control of primordial follicle reawakening by Kit via Foxo3

Tuesday, April 18th

For the GrandRounds on April 18th, Dr. Diego Castrillon from UT Southwestern Medical Center will present on the mechanism of primordial follicle activation.

Diego Castrillon, MD, PhD

Professor and Vernie A Stembridge M.D., Distinguished Chair in Pathology, UT Southwestern Medical Center, Dallas, TX
Dr. Castrillon is a board certified anatomical pathologist, specializing in the diagnosis of obstetric and gynecologic diseases, with a clinical and research emphasis on biomarkers of diseases and early detection; cervical cancer; endometrial cancers and precancers; and ovarian cancer.


Women are born with finite numbers of oocytes stockpiled as primordial follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their growth. Dr. Castrillon’s presentation is based on a recent genetic study, recently published by his laboratory in the journal PLoS ONE, that utilized a novel loss-of-function allele, Kit. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation The presentation provides formal genetic proof that Kit controls oocyte reawakening, focusing future investigations into the causes of primary ovarian insufficiency and ovarian aging.


At the end of the lecture, learners should be able to:

  • Describe the basic circuity operating within the oocyte to control primordial follicle reawakening (activation)
  • Explain the animal and genetic model systems useful to explore this otherwise difficult-to-study biology
  • List the key unanswered questions in the field


Cocktails: 6 PM

Lecture: 7 PM

Complimentary Dinner: 8 PM


Bagatelle Restaurant

1 Little W 12th Street
New York, NY 10014

A Meatpacking District staple and NYC institution, Bagatelle is a French bistro established in 2008 by two Frenchmen. The opulent space, decorated with graffiti art and filled with lively music, has a relaxed yet sexy vibe, reminiscent of a beloved restaurant in Europe. The food is French seasonal, with traditional dishes like the whole roasted chicken with truffles and baby potatoes, and grilled Maine lobster served over linguine with a secret sauce.

The Center for Human Reproduction (CHR) has, following its charter, for over 20 years been an independent provider of complimentary continuous medical education. CHR takes full responsibility for balance, objectivity and scientific rigor of all information presented. Selection of speakers, topics and content is independent of all outside commercial interests. These events accept reservation on a first-come, first-served basis.

Eligibility criteria for free admission: (i) actively practicing physicians in specialty areas relating to reproduction; ii) medical students; iii) scientists in clinical or research area related to reproduction; and iv) journalists working in relevant fields. If you are registering for the first time this academic year, please email a copy of your professional ID with this registration. Space permitting, interested parties who do not qualify for free admission will be offered admission for a donation of $150 at the door to the Foundation of Reproductive Medicine, which co-sponsors CHR's GrandRounds. CHR reserves the right to refuse entry to the event once capacity is reached.

Please click here to read a letter from Dr. Gleicher explaining the re-focusing and expansion of our GrandRounds.

To reserve your seat, please fill out the reservation form below:

Are you actively practicing now?*

Additional Resources

Watch out for snake oil: PGS, “ovarian rejuvenation” and mo... Since there is important new information for infertility patients to be disseminated, we decided to shorten the summer hiatus for


In Focus: Human blastocyst and trophectoderm Here is an image of a human blastocyst that has been labeled to demonstrate the contact points between cells making

Get a Second Opinion
second opinion cta

1/3 of women who have been told they need egg donation actually wind up conceiving at the CHR with their own eggs.